tert-butyl N-[(1S)-2-methyl-1-[4-[[2-oxo-2-[4-(2-phenylmethoxyphenyl)-1H-indol-3-yl]ethyl]carbamoyl]-1,3-oxazol-2-yl]propyl]carbamate | 334636-14-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: tert-butyl N-[(1S)-2-methyl-1-[4-[[2-oxo-2-[4-(2-phenylmethoxyphenyl)-1H-indol-3-yl]ethyl]carbamoyl]-1,3-oxazol-2-yl]propyl]carbamate
• CAS: 334636-14-5
• 化学式: C₃₆H₃₈N₄O₆
• 分子量: 622.721
• InChiKey: WGCPKLUPTIISAX-YTTGMZPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  46
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[(1S)-2-methyl-1-[4-[[2-oxo-2-[4-(2-phenylmethoxyphenyl)-1H-indol-3-yl]ethyl]carbamoyl]-1,3-oxazol-2-yl]propyl]carbamate 、 alkaline earth salt of/the/ methylsulfuric acid 在 伯吉斯试剂 作用下， 生成 4-(2-Benzyloxy-phenyl)-3-[2'-((S)-1-tert-butoxycarbonylamino-2-methyl-propyl)-[2,4']bioxazolyl-5-yl]-indole-1-carboxylic acid methyl ester
  参考文献：
  名称：

  Vilsmeier methodology for the synthesis of 3-(2-N-phthaloylacyl)indole derivatives, and its application to the synthesis of the GCDEF rings of diazonamide

  摘要：

  The synthesis of the GCDEF fragment of diazonamide was achieved using a modified Vilsmeier procedure that allows ready access to 3-(2-N-phthaloylacyl)indole derivatives. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)02023-2
• 作为产物：
  描述：

  4-<2-<(S)-1-tert-butyloxycarbonylamino-2-methylpropyl>>-oxazole carboxylic acid 、 2-amino-1-[4-(2-phenylmethoxyphenyl)-1H-indol-3-yl]ethanone 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 tert-butyl N-[(1S)-2-methyl-1-[4-[[2-oxo-2-[4-(2-phenylmethoxyphenyl)-1H-indol-3-yl]ethyl]carbamoyl]-1,3-oxazol-2-yl]propyl]carbamate
  参考文献：
  名称：

  Vilsmeier methodology for the synthesis of 3-(2-N-phthaloylacyl)indole derivatives, and its application to the synthesis of the GCDEF rings of diazonamide

  摘要：

  The synthesis of the GCDEF fragment of diazonamide was achieved using a modified Vilsmeier procedure that allows ready access to 3-(2-N-phthaloylacyl)indole derivatives. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)02023-2

文献信息

• Vilsmeier methodology for the synthesis of 3-(2-N-phthaloylacyl)indole derivatives, and its application to the synthesis of the GCDEF rings of diazonamide
  作者：Jennifer D Kreisberg、Philip Magnus、Edward G McIver

  DOI：10.1016/s0040-4039(00)02023-2

  日期：2001.1

  The synthesis of the GCDEF fragment of diazonamide was achieved using a modified Vilsmeier procedure that allows ready access to 3-(2-N-phthaloylacyl)indole derivatives. (C) 2001 Elsevier Science Ltd. All rights reserved.