3-[[(2R,3S)-1,2-dihydroxy-5-oxopentan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[[(2R,3S)-1,2-dihydroxy-5-oxopentan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
• 化学式: C₁₄H₂₇N₂O₅P
• 分子量: 334.35
• InChiKey: YKTQYTBPURXDRU-NSCHKWSVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  22
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] NUCLEIC ACID REGULATION OF GROWTH ARREST-SPECIFIC PROTEIN 6 (GAS6)<br/>[FR] RÉGULATION PAR LES ACIDES NUCLÉIQUES DE LA PROTÉINE SPÉCIFIQUE DE L'ARRÊT DE CROISSANCE 6 (GAS6)
  申请人：NOVAMEDICA LTD LIABILITY COMPANY

  公开号：WO2014066142A1

  公开（公告）日：2014-05-01

  The present disclosure generally relates to a pharmacologic system to modulate the biology of platelets based upon nucleic acid ligands that can interact with and modulate the activity of Growth Arrest-Specific gene 6 (GAS6) protein. These nucleic acid ligands are actively reversible using a modulator that inhibits the activity of the nucleic acid ligand and neutralizes its pharmacologic effect, thereby restoring GAS6 function. Also provided are compositions comprising the nucleic acid ligand, the ligand and a modulator, methods to generate the nucleic acid ligand and its modulator, methods to characterize the nucleic acid ligand, and methods of using these agents and compositions in medical therapeutic and diagnostic procedures.