N-[3-[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]-3-fluoroazetidine-1-sulfonamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[3-[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]-3-fluoroazetidine-1-sulfonamide
• 化学式: C₂₄H₁₉F₃N₆O₃S
• 分子量: 528.5
• InChiKey: AVJMEPHWKZXARF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
  申请人：Plexxikon Inc.

  公开号：US20170157120A1

  公开（公告）日：2017-06-08

  Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

  描述了对蛋白激酶活性有影响的化合物，以及制备和使用这些化合物来治疗与蛋白激酶异常活性相关的疾病和症状的方法。
• COMPOUNDS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
  申请人：Plexxikon Inc.

  公开号：US20140357612A1

  公开（公告）日：2014-12-04

  Compounds active on protein kinases and methods for regulating protein kinase pathways are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

  本文介绍了活性对蛋白激酶的化合物以及调节蛋白激酶途径的方法，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。
• Compounds for kinase modulation, and indications therefor
  申请人：Plexxikon Inc.

  公开号：US10421761B2

  公开（公告）日：2019-09-24

  Compounds active on protein kinases and methods for regulating protein kinase pathways are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

  本文介绍了对蛋白激酶有活性的化合物和调节蛋白激酶通路的方法，以及使用此类化合物治疗与蛋白激酶活性异常有关的疾病和病症的方法。
• Compounds and methods for kinase modulation, and indications therefor
  申请人：Plexxikon Inc.

  公开号：US11337976B2

  公开（公告）日：2022-05-24

  Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

  描述了对蛋白激酶有活性的化合物，以及制造和使用这种化合物来治疗与蛋白激酶活性异常有关的疾病和病症的方法。
• PROCESS OF POLYMERIZATION CATALYST PRODUCTION WITH CONTROLLED CATALYST PROPERTIES AND USE OF SAME IN OLEFIN POLYMERIZATIONS
  申请人：BASF Corporation

  公开号：US20140128556A1

  公开（公告）日：2014-05-08

  Solid catalyst components for use in olefin polymerization, olefin polymerization catalyst systems containing the solid catalyst components, methods of making the solid catalyst components and the catalyst systems, and methods of polymerizing and copolymerizing olefins involving the use of the catalyst systems. The solid catalyst components are formed by (a) dissolving a magnesium compound and an auxiliary intermediate electron donor in at least one first solvent to form a solution; (b) contacting a first titanium compound with said solution to form a precipitate of the magnesium compound and the first titanium compound; (c) washing the precipitate with a mixture of a second titanium compound and at least one second solvent and optionally an electron donor at a temperature of up to 90° C.; and (d) treating the precipitate with a mixture of a third titanium compound and at least one third solvent at 90-150° C. to form a solid catalyst component.