(2-fluoro-3-pyrrolidin-1-ylphenyl)-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-fluoro-3-pyrrolidin-1-ylphenyl)-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone
• 化学式: C₂₃H₁₉FN₄O
• 分子量: 386.4
• InChiKey: NVFVKMYLHJCHSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  61.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
  申请人：Ibrahim Prabha N.

  公开号：US20140128373A1

  公开（公告）日：2014-05-08

  Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

  描述了对蛋白激酶活性有效的化合物，以及制备和使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病况的方法。
• COMPOUNDS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
  申请人：PLEXXIKON INC.

  公开号：EP3004060A1

  公开（公告）日：2016-04-13
• [EN] COMPOUNDS FOR KINASE MODULATION, AND INDICATIONS THEREFOR<br/>[FR] COMPOSÉS POUR MODULATION DE KINASES, ET INDICATIONS CORRESPONDANTES
  申请人：PLEXXIKON INC

  公开号：WO2014194127A1

  公开（公告）日：2014-12-04

  Compounds active on protein kinases and methods for regulating protein kinase pathways are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.