6-amino-5-[[(3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-1H-pyrimidin-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-amino-5-[[(3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-1H-pyrimidin-2-one
• 化学式: C₁₁H₁₈N₄O₆
• 分子量: 302.28
• InChiKey: AXXURXKMGDZZPP-OXNFMAJFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  173
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• Mapping cytosine modifications
  申请人：New England Biolabs, Inc.

  公开号：US10081827B2

  公开（公告）日：2018-09-25

  Methods, compositions and kits for selectively altering and detecting modified cytosine residues are provided.

  提供了选择性改变和检测修饰胞嘧啶残基的方法、组合物和试剂盒。
• Mapping Cytosine Modifications
  申请人：NEW ENGLAND BIOLABS, INC.

  公开号：US20140127678A1

  公开（公告）日：2014-05-08

  Methods, compositions and kits for selectively altering and detecting modified cytosine residues are provided.
• US9267117B2
  申请人：——

  公开号：US9267117B2

  公开（公告）日：2016-02-23
• [EN] MAPPING CYTOSINE MODIFICATIONS<br/>[FR] CARTOGRAPHIE DE MODIFICATION DE CYTOSINE
  申请人：NEW ENGLAND BIOLABS INC

  公开号：WO2014074450A1

  公开（公告）日：2014-05-15

  Methods, compositions and kits for selectively altering and detecting modified cytosine residues are provided.
• [EN] DETECTION OF EPIGENETIC STATUS USING SEQUENCE-SPECIFIC DEGRADATION<br/>[FR] DÉTECTION D'ÉTAT ÉPIGÉNÉTIQUE À L'AIDE D'UNE DÉGRADATION SPÉCIFIQUE À UNE SÉQUENCE
  申请人：[en]GUARDANT HEALTH, INC.

  公开号：WO2022147420A1

  公开（公告）日：2022-07-07

  Provided herein is a method of analyzing DNA comprising a procedure that affects a first nucleobase in the DNA differently from a second nucleobase in the DNA; sequence-specifically degrading target sequences in the DNA; and detecting target sequences that are not degraded. Also provided is a combination comprising a population of DNA and a sequence-specific nuclease, wherein the population comprises or was derived from DNA with a cytosine modification, and wherein the population comprises a first, converted nucleobase and a second nucleobase without altered base pairing specificity; wherein the form of the first nucleobase originally present in the DNA prior to alteration of base pairing specificity and the second nucleobase have the same base pairing specificity.