N-(3-acetylphenyl)-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]butanamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(3-acetylphenyl)-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]butanamide
• 化学式: C₁₈H₂₈N₂O₄
• 分子量: 336.4
• InChiKey: JSUVKHPIJMCWQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  87.7
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Agonists of Guanylate Cyclase Useful For the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
  申请人：SYNERGY PHARMACEUTICALS INC.

  公开号：US20140135274A1

  公开（公告）日：2014-05-15

  The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition including Crohn's disease and ulcerative colitis, and cancer.
• FORMULATIONS OF GUANYLATE CYCLASE C AGONISTS AND METHODS OF USE
  申请人：SYNERGY PHARMACEUTICALS, INC.

  公开号：US20170202904A1

  公开（公告）日：2017-07-20

  The invention provides low-dose formulations of guanylate cyclase-C (“GCC”) agonist peptides and methods for their use. The formulations of the invention can be administered either alone or in combination with one or more additional therapeutic agents, preferably an inhibitor of cGMP-dependent phosphodiesterase or a laxative.
• US9919024B2
  申请人：——

  公开号：US9919024B2

  公开（公告）日：2018-03-20