(2R,4R,5R)-4-hydroxy-2-methoxy-5-[[2-[2-(2-methoxyethoxy)ethoxycarbonylamino]acetyl]amino]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,4R,5R)-4-hydroxy-2-methoxy-5-[[2-[2-(2-methoxyethoxy)ethoxycarbonylamino]acetyl]amino]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
• 化学式: C₁₈H₃₂N₂O₁₃
• 分子量: 484.5
• InChiKey: FXLJTWDUQILXNN-XQHWYJGDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  33
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  223
• 氢给体数：
  7
• 氢受体数：
  13

文献信息

• Glycopegylated Factor IX
  申请人：NOVO NORDISK A/S

  公开号：US20140112903A1

  公开（公告）日：2014-04-24

  Conjugates between Factor IX and PEG moieties. are disclosed in the present application. The conjugates are linked via a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. Conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
• GLYCOPEGYLATED FOLLICLE STIMULATING HORMONE
  申请人：Novo Nordisk A/S

  公开号：US20150111245A1

  公开（公告）日：2015-04-23

  The invention provides conjugates between follicle stimulating hormone and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
• US8791066B2
  申请人：——

  公开号：US8791066B2

  公开（公告）日：2014-07-29
• US8791070B2
  申请人：——

  公开号：US8791070B2

  公开（公告）日：2014-07-29
• US9050304B2
  申请人：——

  公开号：US9050304B2

  公开（公告）日：2015-06-09