(2E,3Z)-3-(aminomethyl)-2-ethylidene-5-methylhexa-3,5-diene-1,4-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2E,3Z)-3-(aminomethyl)-2-ethylidene-5-methylhexa-3,5-diene-1,4-diol
• 化学式: C₁₀H₁₇NO₂
• 分子量: 183.25
• InChiKey: OTXKPKOWUTXKCY-CCAISUFFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• SUBSTITUTED PYRIDOXINE-LACTAM CARBOXYLATE SALTS
  申请人：Yamin Rina

  公开号：US20110294859A1

  公开（公告）日：2011-12-01

  The present invention provides salt adducts comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, methods of their preparation, and pharmaceutical compositions and medicaments comprising them. Salt adducts of the invention and compositions comprising them may be used to in the treatment of diseases or disorders associated with or inflicted by alcohol consumption.

  本发明提供了盐加合物，其中至少包含一种带有正电荷的基团，为吡ridoxine或其衍生物，以及至少一种羧化的5-到7-成员内酰胺环，可选择性地另外取代，以及其制备方法，以及包含它们的药物组合物和药物。本发明的盐加合物和包含它们的组合物可用于治疗与酒精消费相关或由酒精消费引起的疾病或疾病。
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC DISORDERS
  申请人：Cellixbio Private Limited

  公开号：US20150141468A1

  公开（公告）日：2015-05-21

  The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for treating or preventing metabolic disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be also used to the treatment of diabetes, lipid peroxidation, hypertriglyceridemia, metabolic disorders, free radical generated due to reactive oxygen and carbonyl groups, ionizing radiation, advanced glycation end products, kidney disease, renal complications and kidney stone disease.

  该发明涉及具有化学式I的化合物或其药用可接受的盐，以及其多晶形、溶剂合物、对映体、立体异构体和水合物。包括化合物I的有效量的药物组合物，以及用于治疗或预防代谢紊乱的方法可以制备为口服、颊下、直肠、局部、经皮、经粘膜、静脉、肠道给药、糖浆或注射剂。这种组合物也可用于治疗糖尿病、脂质过氧化、高三酰甘油血症、代谢紊乱、由于活性氧和醛基产生的自由基、电离辐射、高级糖基化终产物、肾病、肾脏并发症和肾结石病。
• SUBSTITUTED PYRIDOXINE-LACTAM CARBOXYLATE-SALTS
  申请人：ALCOBRA LTD.

  公开号：US20150025111A1

  公开（公告）日：2015-01-22

  The present invention provides salt adducts comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, methods of their preparation, and pharmaceutical compositions and medicaments comprising them. Salt adducts of the invention and compositions comprising them may be used to in the treatment of diseases or disorders associated with or inflicted by alcohol consumption,

  本发明提供了盐加合物，包括至少一个带有正电荷的基团，其中该基团为吡哆醇或其衍生物，以及至少一个羧化的5-至7-成员内酰胺环，可选择性地另外取代，其制备方法，以及包含它们的制药组合物和药物。本发明的盐加合物和包含它们的组合物可用于治疗与饮酒有关的疾病或障碍。
• METHOD FOR THE TREATMENT, ALLEVIATION OF SYMPTOMS OF, RELIEVING, IMPROVING AND PREVENTING A COGNITIVE DISEASE, DISORDER OR CONDITION
  申请人：Alcobra Ltd.

  公开号：US20160199362A1

  公开（公告）日：2016-07-14

  The present invention provides uses of a salt adduct comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring, optionally additionally substituted, for the preparation of a medicament for the treatment, alleviation of symptoms of, relieving, improving and preventing a cognitive disease, disorder or condition in a subject. Additionally, the invention provides use of said salt adducts for the preparation of medicaments for the improvement of cognitive functions in a healthy subject.
• US8710067B2
  申请人：——

  公开号：US8710067B2

  公开（公告）日：2014-04-29