1-[(1S)-2,2-dimethylcyclopropyl]-2-methylpropan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[(1S)-2,2-dimethylcyclopropyl]-2-methylpropan-1-one
• 化学式: C₉H₁₆O
• 分子量: 140.22
• InChiKey: SMYNEUWTVWXOAG-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• PHOSPHINE OXIDE ALKYL AMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS MODULATORS OF IL-12, IL-23, AND/OR IFN ALPHA RESPONSES
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20180162889A1

  公开（公告）日：2018-06-14

  Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where all substituents are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.

  具有以下化学式I的化合物，或其立体异构体或药学上可接受的盐，在所有取代基如此定义的情况下，可用于调节IL-12、IL-23和/或IFNα，通过作用于Tyk-2以引起信号转导抑制。
• [EN] COMPOUNDS FOR MODULATING IL-17
  申请人：ENSEMBLE THERAPEUTICS CORPORATION

  公开号：WO2014066726A2

  公开（公告）日：2014-05-01

  [EN] The invention relates generally to compounds and their therapeutic use. More particularly, the invention relates to compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions, such as inflammatory diseases and other IL-17 associated disorders.