N-[1-[3-[3-[5-[3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]-2-[[3-[3-[5-[3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]methyl]-3-[3-[3-[5-[3-amino-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]propan-2-yl]-12-[(2S,4R)-4-hydroxy-2-(methoxymethyl)pyrrolidin-1-yl]-12-oxododecanamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[1-[3-[3-[5-[3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]-2-[[3-[3-[5-[3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]methyl]-3-[3-[3-[5-[3-amino-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]propan-2-yl]-12-[(2S,4R)-4-hydroxy-2-(methoxymethyl)pyrrolidin-1-yl]-12-oxododecanamide
• 化学式: C₇₃H₁₃₅N₁₁O₂₇
• 分子量: 1598.9
• InChiKey: KGPGOYSDYWATCH-CTMMARJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.7
• 重原子数：
  111
• 可旋转键数：
  62
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  576
• 氢给体数：
  19
• 氢受体数：
  30

文献信息

• Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes
  申请人：Bettencourt Brian

  公开号：US20140113957A1

  公开（公告）日：2014-04-24

  The invention relates to double-stranded ribonucleic acid (dsRNA) targeting an APOC3 gene, and methods of using the dsRNA to inhibit expression of APOC3.
• COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：US20160115476A1

  公开（公告）日：2016-04-28

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1.
• SERPINA1 SIRNAS: COMPOSITIONS OF MATTER AND METHODS OF TREATMENT
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20160244752A1

  公开（公告）日：2016-08-25

  The technology described herein relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the Serpina1 gene, and methods of using such dsRNA compositions to inhibit expression of Serpina1.
• COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE LECT2 GENE
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20160264966A1

  公开（公告）日：2016-09-15

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the LECT2 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of LECT2.
• COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF CD274/PD-L1 GENE
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20170067060A1

  公开（公告）日：2017-03-09

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the CD274/PD-L1 gene, and methods of using such dsRNA compositions to inhibit expression of CD274/PD-L1.