N-[3-[3-[3-[3-[3-[5-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]-2-[[3-[3-[5-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]methyl]-2-methylpropoxy]propanoylamino]propyl]-5-[3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[3-[3-[3-[3-[3-[5-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]-2-[[3-[3-[5-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]methyl]-2-methylpropoxy]propanoylamino]propyl]-5-[3-acetamido-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanamide
• 化学式: C₆₂H₁₁₁N₉O₂₆
• 分子量: 1398.6
• InChiKey: OQZWRWGZCZNKKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.3
• 重原子数：
  97
• 可旋转键数：
  51
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  507
• 氢给体数：
  17
• 氢受体数：
  26

文献信息

• Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes
  申请人：Bettencourt Brian

  公开号：US20140113957A1

  公开（公告）日：2014-04-24

  The invention relates to double-stranded ribonucleic acid (dsRNA) targeting an APOC3 gene, and methods of using the dsRNA to inhibit expression of APOC3.
• SERPINA1 SIRNAS: COMPOSITIONS OF MATTER AND METHODS OF TREATMENT
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20160244752A1

  公开（公告）日：2016-08-25

  The technology described herein relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the Serpina1 gene, and methods of using such dsRNA compositions to inhibit expression of Serpina1.
• US9315813B2
  申请人：——

  公开号：US9315813B2

  公开（公告）日：2016-04-19