3-[2-[2-[2-(2-acetamidoethoxy)ethoxy]ethoxy]ethoxy]-N-[1,3-bis[3-[2-[2-[2-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethylamino]-3-oxopropoxy]-2-[[3-[2-[2-[2-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethylamino]-3-oxopropoxy]methyl]propan-2-yl]propanamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[2-[2-[2-(2-acetamidoethoxy)ethoxy]ethoxy]ethoxy]-N-[1,3-bis[3-[2-[2-[2-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethylamino]-3-oxopropoxy]-2-[[3-[2-[2-[2-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethylamino]-3-oxopropoxy]methyl]propan-2-yl]propanamide
• 化学式: C₆₈H₁₂₄N₈O₃₆
• 分子量: 1629.7
• InChiKey: FPDFFFYNXWUETE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -12.3
• 重原子数：
  112
• 可旋转键数：
  67
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  590
• 氢给体数：
  17
• 氢受体数：
  36

文献信息

• Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes
  申请人：Bettencourt Brian

  公开号：US20140113957A1

  公开（公告）日：2014-04-24

  The invention relates to double-stranded ribonucleic acid (dsRNA) targeting an APOC3 gene, and methods of using the dsRNA to inhibit expression of APOC3.
• SERPINC1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：US20160257954A1

  公开（公告）日：2016-09-08

  The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and methods of treating subjects having a bleeding disorder, such as a hemophilia.
• US9315813B2
  申请人：——

  公开号：US9315813B2

  公开（公告）日：2016-04-19