2,8-dimethoxy-(4bc,10bt)-4b,5,6,10b,11,12-hexahydro-chrysene | 54173-10-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 2,8-dimethoxy-(4bc,10bt)-4b,5,6,10b,11,12-hexahydro-chrysene
• 英文别名: 2,8-Dimethoxy-(4bc,10bt)-4b,5,6,10b,11,12-hexahydro-chrysen；2.8-Dimethoxy-(4brH.10btH)-4b.5.6.10b.11.12-hexahydro-chrysen；(4bS,10bR)-2,8-dimethoxy-4b,5,6,10b,11,12-hexahydrochrysene
• CAS: 54173-10-3
• 化学式: C₂₀H₂₂O₂
• 分子量: 294.393
• InChiKey: SKRSOKWQYMAAFM-BGYRXZFFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,8-dimethoxy-(4bc,10bt)-4b,5,6,10b,11,12-hexahydro-chrysene 在 氢碘酸 、 溶剂黄146 作用下， 生成 trans-4b.5.6.10b.11.12-hexahydro-chrysenediol-(2.8)
  参考文献：
  名称：

  Dodds et al., Proceedings of the Royal Society of London. Series B, Biological sciences, 1939, vol. 127, p. 140,153 Anm. 154

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 、 一水合肼 、 乙二醇 作用下， 生成 2,8-dimethoxy-(4bc,10bt)-4b,5,6,10b,11,12-hexahydro-chrysene
  参考文献：
  名称：

  194.改性的synthesis合成

  摘要：

  DOI：

  10.1039/jr9480000999

文献信息

• Dodds et al., Proceedings of the Royal Society of London. Series B, Biological sciences, 1939, vol. 127, p. 140,153 Anm. 154
  作者：Dodds et al.

  DOI：——

  日期：——
• 194. A modified synthesis of chrysene
  作者：G. M. Badger

  DOI：10.1039/jr9480000999

  日期：——
• 415. Hydroaromatic steroid hormones. Part II. Some hydrochrysene derivatives
  作者：Arthur J. Birch、Herchel Smith

  DOI：10.1039/jr9510001882

  日期：——
• The role of M cells in mucosal immunity
  作者：L. J. Hathaway、J.-P. Kraehenbuhl*

  DOI：10.1007/pl00000693

  日期：2000.2

  Mucosa-associated lymphoid tissue in the respiratory and digestive tracts are covered by a specialized epithelium, the follicle-associated epithelium, which includes M cells, which are specialized for the uptake and transcytosis of macromolecules and microorganisms. Following transcytosis, antigens are released to cells of the immune system in lymphoid aggregates beneath the epithelium where antigen processing and presentation and stimulation of specific B and T lymphocytes are achieved. Circulation of the lymphoid cells enables their homing to their original, and other, mucosal sites where they exert the effector function. Such a response may be dominated by secretory immunoglobulin A release and may include cytotoxic T lymphocyte action. Binding of particles to the apical M cell membrane may be nonspecific or due to specific interaction between molecules such as integrins and lectins. Exploiting the specific binding to M cells is an aim for mucosal vaccination, for example to increase the efficiency of uptake of an oral vaccine by its conjugation to an M-cel-specific molecule. Alternatively, an M-cell-specific live vector, such as attenuated Salmonella bacteria, may be used to deliver epitopes of other organisms. Mucosal vaccination efficiency may also be enhanced by a temporary increase in the number of M cells.Therefore, investigation of the properties and ontogeny of M cells must be pursued to allow the development of better mucosal vaccines for the future.
• Cyclic Analogs of Hexestrol in the Chrysene Series
  作者：A. L. Wilds、Reid E. Sutton

  DOI：10.1021/jo50003a006

  日期：1951.9