(Z)-2,2-difluoroundec-8-en-3-yn-5-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Z)-2,2-difluoroundec-8-en-3-yn-5-ol
• 化学式: C₁₁H₁₆F₂O
• 分子量: 202.24
• InChiKey: NAGXJVRCXBXURQ-PLNGDYQASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PREDICTIVE MARKER OF DNMT1 INHIBITOR THERAPEUTIC EFFICACY AND METHODS OF USING THE MARKER
  申请人：Bates Paula J.

  公开号：US20140329911A1

  公开（公告）日：2014-11-06

  Provided herein are methods for predicting efficacy of a DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibitor treatment in a subject having a cancer, methods of identifying a subject having a cancer that is more likely to respond to a DNMT1 inhibitor treatment, and methods of selecting a treatment for a subject having a cancer that include determining a level of SOX9 in a sample containing cells from a subject having a cancer. Also provided are methods of treating a subject having a cancer that include selectively administering a DNMT1 inhibitor to a subject having cancer determined to have an elevated level of SOX9 in a sample containing cells from the subject compared to a reference level. Also provided are antibodies and antigen-binding antibody fragments that specifically bind to SOX9, and nucleic acid sequences that contain at least 10 nucleotides complementary to a contiguous sequence present in a SOX9 nucleic acid for use in these methods.
• COMPOSITIONS AND METHODS FOR MODULATING DNMT1 INHIBITOR ACTIVITY
  申请人：UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.

  公开号：US20150238439A1

  公开（公告）日：2015-08-27

  Some aspects of the invention include attenuating DNMT1 inhibitor activity in an animal comprising administering an antioxidant. Other aspects of the invention include methods comprising administering a composition comprising a DNMT1 inhibitor and an antioxidant. In some instances in the methods, the animal is undergoing a treatment for cancer. Additional aspects of the invention include compositions comprising a DNMT1 inhibitor and an antioxidant.
• US8703829B2
  申请人：——

  公开号：US8703829B2

  公开（公告）日：2014-04-22
• US9383364B2
  申请人：——

  公开号：US9383364B2

  公开（公告）日：2016-07-05
• US9737493B2
  申请人：——

  公开号：US9737493B2

  公开（公告）日：2017-08-22