(3R,4S,5R)-3,4,5,6-tetrahydroxyhexanoyl azide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R,4S,5R)-3,4,5,6-tetrahydroxyhexanoyl azide
• 化学式: C6H11N3O5
• 分子量: 205.17
• InChiKey: VOFVUDQLHOLFTC-KODRXGBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  112
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS
  申请人：Solstice Biologics, Ltd.

  公开号：EP3152308A2

  公开（公告）日：2017-04-12
• [EN] COMPOSITIONS AND METHODS FOR THE TRANSFER OF A HEXOSAMINE TO A MODIFIED NUCLEOTIDE IN A NUCLEIC ACID<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRANSFERT D'UNE HEXOSAMINE À UN NUCLÉOTIDE MODIFIÉ DANS UN ACIDE NUCLÉIQUE
  申请人：NEW ENGLAND BIOLABS INC

  公开号：WO2014074445A1

  公开（公告）日：2014-05-15

  Nucleic acids comprising β-clucosaminyloxy-5-methylcytosine; compositions, kits and methods of producing the nucleic acids using a glycosyltransferase; and methods of using the nucleic acids are described.
• [EN] POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS<br/>[FR] CONSTRUCTIONS DE POLYNUCLÉOTIDES POSSÉDANT DES GROUPES BIORÉVERSIBLES ET NON BIORÉVERSIBLES
  申请人：SOLSTICE BIOLOG LTD

  公开号：WO2015188197A2

  公开（公告）日：2015-12-10

  The invention features a hybridized polynucleotide construct containing a passenger strand, a guide strand loadable into a RISC complex, and (i) a 3'-terminal or an internucleotide non-bioreversible group in the guide strand; or (ii) a 5'-terminal, a 3'-terminal, or an internucleotide non-bioreversible group in the passenger strand, and a 5'-terminal, a 3'-terminal, or an internucleotide disulfide bioreversible group in the guide strand or the passenger strand. The invention also features methods of delivering a polynucleotide to a cell using the hybridized polynucleotide construct. The invention further features methods of reducing the expression of a polypeptide in a cell using the hybridized polynucleotide construct.