(E)-6-[diazenyl(methyl)amino]hex-5-enal

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-6-[diazenyl(methyl)amino]hex-5-enal
• 化学式: C₇H₁₃N₃O
• 分子量: 155.2
• InChiKey: AJBLJSNIYZPGJP-SLFIHTTNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  56.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• MELANOCORTIN 1 RECEPTOR LIGANDS AND METHODS OF USE
  申请人：Gillies Robert J.

  公开号：US20140112873A1

  公开（公告）日：2014-04-24

  The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
• US9441013B2
  申请人：——

  公开号：US9441013B2

  公开（公告）日：2016-09-13