2-[4-[4-(2,2,2-Trifluoroacetyl)phenyl]sulfonyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]acetic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[4-[4-(2,2,2-Trifluoroacetyl)phenyl]sulfonyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]acetic acid
• 英文别名: 2-[4-[4-(2,2,2-trifluoroacetyl)phenyl]sulfonyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]acetic acid
• 化学式: C₁₇H₁₉F₃N₂O₆S
• 分子量: 436.4
• InChiKey: YFTKXYKEBMMAOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• FILAMIN A BINDING ANTI-INFLAMMATORY AND ANALGESIC
  申请人：Burns Barbier Lindsay

  公开号：US20140113895A1

  公开（公告）日：2014-04-24

  A compound or its pharmaceutically acceptable salt, optionally including both individual enantiomeric forms, a racemate, diastereomers and mixtures thereof, composition and method are disclosed that can provide analgesia and reduce inflammation. A contemplated compound has a structure that corresponds to Formula A, wherein the R group substituents, d, e, f, k, n, m, D, E, F, K, G, P, Q, W, and Z are defined within.
• US9340558B2
  申请人：——

  公开号：US9340558B2

  公开（公告）日：2016-05-17