(2R,3S,5R)-6-(hydroxymethyl)-3-methyloxane-2,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,5R)-6-(hydroxymethyl)-3-methyloxane-2,4,5-triol
• 化学式: C₇H₁₄O₅
• 分子量: 178.18
• InChiKey: YVJXTNFYGMZWPR-NPOUAQDBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• LABELING AND DETECTION OF POST TRANSLATIONALLY MODIFIED PROTEINS
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US20150051096A1

  公开（公告）日：2015-02-19

  Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling a biomolecules with an azide group.

  在某些实施例中，提供了一种形成含偶氮基改性生物分子共轭物的报告分子、载体分子或固体支持的新方法。在其他实施例中，提供了一种用酶标记含偶氮基的生物分子的方法。
• MULTIPLE-ENZYME NANOCOMPLEXES
  申请人：Lu Yunfeng

  公开号：US20140134700A1

  公开（公告）日：2014-05-15

  Provided are nanocomplexes having at least two different enzymes and a polymeric network anchored to at least one of the enzymes. In some embodiments, the activities of the enzymes catalyze a cascade reaction.
• NOVEL OLIGONUCLEOTIDE CONJUGATES AND USE THEREOF
  申请人：Bioneer Corporation

  公开号：US20140371432A1

  公开（公告）日：2014-12-18

  The present invention provides a double-stranded RNA structure, which comprises a polymer compound covalently bonded to a double-helix oligo RNA useful for the treatment of diseases, particularly cancer, in order to enhance the delivery of the double-helix oligo RNA, and further comprises a target-specific ligand bonded thereto, a preparation method thereof, and a technique of delivering the double-helix oligo RNA in a target-specific manner using the RNA structure. A nanoparticle composed of the ligand-bonded double-helix oligo RNA structures can efficiently deliver the double-helix oligo RNA to a target, and thus can exhibit the activity of the double-helix oligo RNA even when the double-helix oligo RNA is administered at a relatively low concentration. Also, it can prevent the non-specific delivery of the double-helix oligo RNA into other organs and cells. Accordingly, the ligand-bonded double-stranded RNA structure can be used for the treatment for various diseases, particularly cancer, and can also be effectively used as a new type of double-helix oligo RNA delivery system. Particularly, the ligand-bonded double-stranded RNA structure can be effectively used for the treatment of diseases, including cancer and infectious diseases. Moreover, the present invention relates to a hybrid conjugate, which comprises a hydrophilic material and hydrophobic material bonded to both ends of an antisense oligonucleotide (ASO) by a covalent bond in order to enhance the in vivo stability of the ASO, a method for preparing the hybrid conjugate, and a nanoparticle composed of the conjugates. The ASO-polymer conjugate according to the invention can increase the in vivo stability of the ASO, making it possible to efficiently deliver the therapeutic ASO into cells. Also, the ASO-polymer conjugate can exhibit the activity of the ASO even when it is administered at a relatively low concentration.
• US9645140B2
  申请人：——

  公开号：US9645140B2

  公开（公告）日：2017-05-09