3-[2,2-Bis(fluoromethoxymethyl)-3-(3-oxobutoxy)propoxy]propanoic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[2,2-Bis(fluoromethoxymethyl)-3-(3-oxobutoxy)propoxy]propanoic acid
• 英文别名: 3-[2,2-bis(fluoromethoxymethyl)-3-(3-oxobutoxy)propoxy]propanoic acid
• 化学式: C₁₄H₂₄F₂O₇
• 分子量: 342.33
• InChiKey: VTXKTIOEWRCDBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  23
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVES, CONJUGATES AND GELS OF PHARMACEUTICALS AND THE SAME
  申请人：JENKEM TECHNOLOGY CO., LTD, TIANJIN BRANCH

  公开号：US20140135486A1

  公开（公告）日：2014-05-15

  A multi-arm polyethylene glycol (I) having different kinds of reactive groups and the uses thereof are disclosed, which is formed by polymerizing ethylene oxide with oligo-pentaerythritol as an initiator, wherein, PEG is same or different and is —(CH2CH2O)m—, the average value of m is an integer of 2-250; l is an integer of 1 or more. The method for producing the multi-arm polyethylene glycol having different kinds of reactive groups, the multi-arm polyethylene glycol active derivatives comprising linking groups X attached to PEG and terminal reactive groups F attached to X, the gels formed by the multi-arm polyethylene glycol active derivatives, the drug conjugates formed by the multi-arm polyethylene glycol active derivatives and drug molecules, and the uses thereof in preparing drugs are also disclosed.