(3,5-Dibromo-4-hydroxyphenyl)-(2-ethyl-6-methyl-1-benzofuran-3-yl)methanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3,5-Dibromo-4-hydroxyphenyl)-(2-ethyl-6-methyl-1-benzofuran-3-yl)methanone
• 英文别名: (3,5-dibromo-4-hydroxyphenyl)-(2-ethyl-6-methyl-1-benzofuran-3-yl)methanone
• 化学式: C₁₈H₁₄Br₂O₃
• 分子量: 438.1
• InChiKey: GTAZMQIYQRXLIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Heterocyclic degronimers for target protein degradation
  申请人：C4 Therapeutics, Inc.

  公开号：US10646575B2

  公开（公告）日：2020-05-12

  This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.

  本发明提供了能与 E3 泛素连接酶（通常是通过脑龙）（"Degrons"）结合的杂环化合物，这些杂环化合物可用于治疗目的或与选定靶蛋白的靶向配体相连接，并提供了其使用方法和组合物及其制备方法。
• Spirocyclic degronimers for target protein degradation
  申请人：C4 Therapeutics, Inc.

  公开号：US10660968B2

  公开（公告）日：2020-05-26

  This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

  本发明提供了具有螺环 E3 泛素连接酶靶向基团（Degrons）的化合物，这些化合物可单独使用，也可与用于体内降解的蛋白质的靶向配体连接，本发明还提供了其使用方法和组合物及其制备方法。
• C3-carbon linked glutarimide degronimers for target protein degradation
  申请人：C4 Therapeutics, Inc.

  公开号：US10849982B2

  公开（公告）日：2020-12-01

  This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

  本发明提供了具有碳连接的 E3 泛素连接酶靶向分子（Degronimers）的 Degronimers（Degronons），这些 Degronimers 可与用于体内降解的蛋白质的靶向配体连接，本发明还提供了其使用方法和组合物及其制备方法。
• USE OF SMALL MOLECULE INHIBITORS TARGETING EYA TYROSINE PHOSPHATASE
  申请人：Children's Hospital Medical Center

  公开号：US20140128460A1

  公开（公告）日：2014-05-08

  Inhibitors of EYA tyrosine phosphatase are provided herein, as well as pharmaceutical compositions and methods relating thereto.
• US9725430B2
  申请人：——

  公开号：US9725430B2

  公开（公告）日：2017-08-08