[6-[7-[4-[(3-Dimethylphosphorylphenyl)carbamoylamino]-2-fluorophenoxy]thieno[3,2-b]pyridin-2-yl]pyridin-3-yl]methyl-(2-methoxyethyl)carbamic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [6-[7-[4-[(3-Dimethylphosphorylphenyl)carbamoylamino]-2-fluorophenoxy]thieno[3,2-b]pyridin-2-yl]pyridin-3-yl]methyl-(2-methoxyethyl)carbamic acid
• 英文别名: [6-[7-[4-[(3-dimethylphosphorylphenyl)carbamoylamino]-2-fluorophenoxy]thieno[3,2-b]pyridin-2-yl]pyridin-3-yl]methyl-(2-methoxyethyl)carbamic acid
• 化学式: C₃₂H₃₁FN₅O₆PS
• 分子量: 663.7
• InChiKey: ZGDLFUTUHUWSMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  46
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  171
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• METHODS OF INHIBITING PROTEIN TYROSINE KINASE ACTIVITY
  申请人：MethylGene Inc.

  公开号：US20140179632A1

  公开（公告）日：2014-06-26

  This invention relates to methods for inhibiting kinase activity and/or inhibiting angiogenesis and/or treating a disease responsive to inhibition of kinase activity and/or treating a cell proliferative disease and/or treating an ophthalmic disease, condition or disorder treating cell proliferative diseases and conditions and opthalmological diseases, disorders and conditions comprising administering novel compounds that inhibit protein tyrosine kinase activity.

  本发明涉及抑制激酶活性和/或抑制血管生成和/或治疗对抑制激酶活性有响应的疾病和/或治疗细胞增殖性疾病和/或治疗眼科疾病、情况或障碍，治疗细胞增殖性疾病和情况和眼科疾病、障碍和情况的方法，包括给予抑制蛋白酪氨酸激酶活性的新化合物。
• US8729268B2
  申请人：——

  公开号：US8729268B2

  公开（公告）日：2014-05-20