oxiran-2-ylmethyl 9H-carbazole-9-carboxylate | 1429244-46-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: oxiran-2-ylmethyl 9H-carbazole-9-carboxylate
• 英文别名: Oxiran-2-ylmethyl carbazole-9-carboxylate；oxiran-2-ylmethyl carbazole-9-carboxylate
• CAS: 1429244-46-1
• 化学式: C₁₆H₁₃NO₃
• 分子量: 267.284
• InChiKey: SISHGPZJGPFUST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  43.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  oxiran-2-ylmethyl 9H-carbazole-9-carboxylate 、 苯胺 以 氯苯 为溶剂， 反应 6.0h， 以20%的产率得到2-hydroxy-3-(phenylamino)propyl 9H-carbazole-9-carboxylate
  参考文献：
  名称：

  Use of tosylated glycerol carbonate to access N-glycerylated aza-aromatic species

  摘要：

  Tosylated glycerol carbonate was used for N-glyceryl functionalization of diverse aza-aromatic systems. Depending on the plc of the aza-heterocycle and the reaction conditions applied, original N-alkylated or N-acylated aza-heterocyclic derivatives were obtained. Those compounds carry an electrophilic appendage-either carbonate or epoxide-which allows further useful transformations. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.03.002
• 作为产物：
  描述：

  3-O-tosyl glycerol 1,2-carbonate 、 咔唑 以 四氢呋喃 、 mineral oil 为溶剂， 反应 12.25h， 以64%的产率得到oxiran-2-ylmethyl 9H-carbazole-9-carboxylate
  参考文献：
  名称：

  Use of tosylated glycerol carbonate to access N-glycerylated aza-aromatic species

  摘要：

  Tosylated glycerol carbonate was used for N-glyceryl functionalization of diverse aza-aromatic systems. Depending on the plc of the aza-heterocycle and the reaction conditions applied, original N-alkylated or N-acylated aza-heterocyclic derivatives were obtained. Those compounds carry an electrophilic appendage-either carbonate or epoxide-which allows further useful transformations. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.03.002

文献信息

• Use of tosylated glycerol carbonate to access N-glycerylated aza-aromatic species
  作者：Gytė Vilkauskaitė、Sonata Krikštolaitytė、Osvaldas Paliulis、Patrick Rollin、Arnaud Tatibouët、Algirdas Šačkus

  DOI：10.1016/j.tet.2013.03.002

  日期：2013.5

  Tosylated glycerol carbonate was used for N-glyceryl functionalization of diverse aza-aromatic systems. Depending on the plc of the aza-heterocycle and the reaction conditions applied, original N-alkylated or N-acylated aza-heterocyclic derivatives were obtained. Those compounds carry an electrophilic appendage-either carbonate or epoxide-which allows further useful transformations. (C) 2013 Elsevier Ltd. All rights reserved.