3-Methoxy-1,4-di(propan-2-yl)pyrazole

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Methoxy-1,4-di(propan-2-yl)pyrazole
• 英文别名: 3-methoxy-1,4-di(propan-2-yl)pyrazole
• 化学式: C₁₀H₁₈N₂O
• 分子量: 182.26
• InChiKey: KNGUKVWBIVGWSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS<br/>[FR] PYRAZOLO[4,3-D]PYRIMIDINES UTILES EN TANT QU'INHIBITEURS DE KINASES
  申请人：ORIGENIS GMBH

  公开号：WO2014060112A1

  公开（公告）日：2014-04-24

  The present invention relates to novel compounds of formula (I) that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, alzheimer's disease, parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.

  本发明涉及具有式（I）的新化合物，其能够抑制一个或多个激酶，特别是SYK（脾酪氨酸激酶）、LRRK2（富含亮氨酸重复的激酶2）和/或MYLK（肌球蛋白轻链激酶）或其突变体。这些化合物可用于治疗多种疾病。这些疾病包括自身免疫疾病、炎症性疾病、骨疾病、代谢性疾病、神经和神经退行性疾病、癌症、心血管疾病、过敏、哮喘、阿尔茨海默病、帕金森病、皮肤疾病、眼部疾病、传染病和激素相关疾病。
• SUBSTITUTED SULFONAMIDE COMPOUNDS
  申请人：Genentech, Inc.

  公开号：US20160264567A1

  公开（公告）日：2016-09-15

  The invention is concerned with the compounds of formula I: and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.

  本发明涉及以下式子的化合物：I，并且包括其盐和其他式子II-IX的化合物，如本文所述。此外，本发明涉及制造和使用式I-IX化合物的方法，以及含有这些化合物的药物组合物。这些化合物可能对治疗由TRPA1介导的疾病和状况，例如疼痛或哮喘，有用。
• Sulfonyl pyridyl TRP inhibitors
  申请人：Genentech, Inc.

  公开号：US10695348B2

  公开（公告）日：2020-06-30

  The invention provides compounds of formula I: and pharmaceutically acceptable salts thereof where R1 is a substituted or unsubstituted phenyl or a fused bicyclic comprising a substituted or unsubstituted phenyl. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

  本发明提供了式 I 的化合物： 及其药学上可接受的盐，其中 R1 是取代或未取代的苯基或包含取代或未取代苯基的融合双环。此外，本发明还涉及式 I 化合物的制造方法和使用方法，以及含有此类化合物的药物组合物。这些化合物可用于治疗由 TRPA1 介导的疾病和病症，如疼痛。
• SULFONYL PYRIDYL TRP INHIBITORS
  申请人：Genentech, Inc.

  公开号：US20190167681A1

  公开（公告）日：2019-06-06

  The invention provides compounds of formula I: and pharmaceutically acceptable salts thereof where R 1 is a substituted or unsubstituted phenyl or a fused bicyclic comprising a substituted or unsubstituted phenyl. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.