1-[4-(2,2-Dimethylpropyl)cyclohexyl]-2,2-dimethylpropan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-(2,2-Dimethylpropyl)cyclohexyl]-2,2-dimethylpropan-1-one
• 英文别名: 1-[4-(2,2-dimethylpropyl)cyclohexyl]-2,2-dimethylpropan-1-one
• 化学式: C₁₆H₃₀O
• 分子量: 238.41
• InChiKey: FMTSMNOUKSPCMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES
  申请人：REGENTS OF THE UNIVERSITY OF MINNESOTA

  公开号：US20170217960A1

  公开（公告）日：2017-08-03

  The invention provides compounds of formula I: wherein R 1 —R 3 , R a , and R b have any of the values defined herein, and salts thereof. The compounds have immunomodulatory properties.

  该发明提供了公式I的化合物：其中R1至R3，Ra和Rb具有本文中定义的任何值，及其盐。这些化合物具有免疫调节特性。
• Cytotoxic peptides and conjugates thereof
  申请人：NOVARTIS AG

  公开号：US10280139B2

  公开（公告）日：2019-05-07

  Disclosed herein are novel compounds of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

  本文公开了如本文所述的新型式 (I) 化合物： 本发明还描述了免疫结合剂（即抗体药物结合剂），其包含与抗原结合分子（如抗体）连接的此类新型化合物；其中此类免疫结合剂可用于治疗细胞增殖性疾病。本发明进一步提供了包含这些免疫共轭物的药物组合物、包含这些免疫共轭物与治疗共用试剂的组合物，以及使用这些免疫共轭物和组合物治疗细胞增殖障碍的方法。
• Antibody adjuvant conjugates
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US11110178B2

  公开（公告）日：2021-09-07

  The invention provides an immunoconjugate comprising an antibody construct which includes an antigen binding domain and an Fc domain, an adjuvant moiety, and a linker, wherein each adjuvant moiety is covalently bonded to the antibody via the linker. Methods for treating cancer with the immunoconjugates of the invention are also described.

  本发明提供了一种免疫结合剂，它包括一种抗体构建体，该抗体构建体包括一个抗原结合结构域和一个Fc结构域、一个佐剂分子和一个连接体，其中每个佐剂分子通过连接体与抗体共价结合。此外，还介绍了用本发明的免疫共轭物治疗癌症的方法。
• Immunomodulators and immunomodulator conjugates
  申请人：REGENTS OF THE UNIVERSITY OF MINNESOTA

  公开号：US11279701B2

  公开（公告）日：2022-03-22

  The invention provides a method for stimulating an immune response in an animal with a compound of formula: or a pharmaceutically acceptable salt thereof, wherein R1-R3, Ra, and Rb have any of the values defined herein.

  本发明提供了一种用式化合物刺激动物免疫反应的方法： 或其药学上可接受的盐，其中 R1-R3、Ra 和 Rb 具有本文定义的任一值。
• METHOD OF TREATING ATHEROSCLEROSIS IN HIGH TRIGLYCERIDE SUBJECTS
  申请人：NOVARTIS AG

  公开号：US20140134262A1

  公开（公告）日：2014-05-15

  The present invention provides a compound of Formula I: for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP activity, such as atherosclerosis and dyslipidemia, in a subject with high triglyceride level; wherein R 1 , X 1 , R 7 , R 5 , C, L and p are defined herein. The present invention further provides a combination of pharmacologically active agents for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP activity, such as atherosclerosis and dyslipidemia, in a subject with high triglyceride levels.