N-[7-bromo-5-(iminoazaniumylideneamino)-6-oxoheptyl]carbamate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[7-bromo-5-(iminoazaniumylideneamino)-6-oxoheptyl]carbamate
• 化学式: C8H13BrN4O3
• 分子量: 293.12
• InChiKey: HQNDDHSIOAMGCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.03
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NON-PEPTIDIC QUENCHED FLUORESCENT IMAGING PROBES
  申请人：Bogyo Matthew S.

  公开号：US20140140930A1

  公开（公告）日：2014-05-22

  Methods and materials for the imaging of cells and tissues containing active proteases such as cathepsin are disclosed. The present materials include activity based probes that bind to an enzyme and are subsequently cleaved. Cleavage results in covalent attachment of a fluorescent signal to a target protease due to removal of a quenching group which, when present on the probe causes altered or no fluorescence. The probes are non-peptidic, small molecule scaffolds linked to a reactive acyloxymethyl ketone group, a fluorophore and a quencher. The probes are cell permeable and may use, for example, a QSY21 (CAS 304014-13-9) quencher and a cyanine dye. The probes form covalent bonds with the active site of cysteine cathepsins, proteases that are upregulated at the tumor boundaries with normal tissue and at sites of inflammation.
• US9180209B2
  申请人：——

  公开号：US9180209B2

  公开（公告）日：2015-11-10