sodium;[(2R,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl] carbonate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: sodium;[(2R,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl] carbonate
• 化学式: C19H31NaO18
• 分子量: 570.4
• InChiKey: ULRTZNYBYQUCTB-HNNWOXMSSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -11.2
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  298
• 氢给体数：
  10
• 氢受体数：
  18

文献信息

• Rapid-acting insulin formulation comprising a substituted anionic compound
  申请人：ADOCIA

  公开号：US10583175B2

  公开（公告）日：2020-03-10

  A composition in aqueous solution includes insulin and at least one substituted anionic compound chosen from substituted anionic compounds consisting of a backbone formed from a discrete number u of between 1 and 8 (1≤u≤8) of identical or different saccharide units, linked via identical or different glycoside bonds, the saccharide units being chosen from the group consisting of hexoses, in cyclic form or in open reduced form, said compound comprising partially substituted carboxyl functional groups, the unsubstituted carboxyl functional groups being salifiable. A pharmaceutical formulation including the composition is also set forth.

  一种水溶液中的组合物包括胰岛素和至少一种取代的阴离子化合物，该化合物选自取代的阴离子化合物，其骨架由相同或不同的糖苷键连接的离散数u（1≤u≤8）组成，这些糖苷键由相同或不同的糖苷单位组成，这些糖苷单位选自由环状或开放还原型的己糖组成的组，所述化合物包括部分取代的羧基官能团，未取代的羧基官能团是可销售的。还提出了一种包括该组合物的药物制剂。
• Unkown
  申请人：ADOCIA

  公开号：US20140142034A1

  公开（公告）日：2014-05-22

  The invention relates to a composition in aqueous solution, including insulin and at least one substituted anionic compound chosen from substituted anionic compounds consisting of a backbone formed from a discrete number u of between 1 and 8 (1≦u≦8) of identical or different saccharide units, linked via identical or different glycoside bonds, said saccharide units being chosen from the group consisting of hexoses, in cyclic form or in open reduced form, said compound comprising partially substituted carboxyl functional groups, the unsubstituted carboxyl functional groups being salifiable. The invention also relates to a pharmaceutical formulation comprising a composition as claimed in any one of the preceding claims.
• RAPID-ACTING INSULIN FORMULATION COMPRISING A SUBSTITUTED ANIONIC COMPOUND
  申请人：ADOCIA

  公开号：US20140378373A2

  公开（公告）日：2014-12-25

  The invention relates to a composition in aqueous solution, including insulin and at least one substituted anionic compound chosen from substituted anionic compounds consisting of a backbone formed from a discrete number u of between 1 and 8 (1≦u≦8) of identical or different saccharide units, linked via identical or different glycoside bonds, said saccharide units being chosen from the group consisting of hexoses, in cyclic form or in open reduced form, said compound comprising partially substituted carboxyl functional groups, the unsubstituted carboxyl functional groups being saliflable. The invention also relates to a pharmaceutical formulation comprising a composition as claimed in any one of the preceding claims.
• US9700599B2
  申请人：——

  公开号：US9700599B2

  公开（公告）日：2017-07-11