6,16-Bis(diethylamino)-20-methoxy-3,10-dimethyl-5,7,12,15,17-pentazapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-1(21),2(11),3,5,9,13,15,19-octaene-8,18-dione | 1204175-91-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6,16-Bis(diethylamino)-20-methoxy-3,10-dimethyl-5,7,12,15,17-pentazapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-1(21),2(11),3,5,9,13,15,19-octaene-8,18-dione
• 英文别名: 6,16-bis(diethylamino)-20-methoxy-3,10-dimethyl-5,7,12,15,17-pentazapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-1(21),2(11),3,5,9,13,15,19-octaene-8,18-dione
• CAS: 1204175-91-6
• 化学式: C₂₇H₃₃N₇O₃
• 分子量: 503.604
• InChiKey: YLPKPEPEYIOKGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,8-diamino-1,4-dimethyl-6-methoxy-9H-carbazole 、 二乙胺 、 异硫氰酰甲酸乙酯 在 mercury dichloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以40%的产率得到6,16-Bis(diethylamino)-20-methoxy-3,10-dimethyl-5,7,12,15,17-pentazapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-1(21),2(11),3,5,9,13,15,19-octaene-8,18-dione
  参考文献：
  名称：

  A rapid and versatile synthesis of novel pyrimido[5,4-b]carbazoles

  摘要：

  A one-pot synthesis of 2-dialkylamino-5,11-dimethyl-6H-pyrimido[5,4-b]carbazol-4(3H)-ones, as new ellipticine analogs, starting from aminocarbazole derivatives is reported. This method allowed us to prepare a library of potentially useful compounds in the pharmaceutical field. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.10.025

文献信息

• A rapid and versatile synthesis of novel pyrimido[5,4-b]carbazoles
  作者：Anna Caruso、Jean-Charles Lancelot、Hussein El-Kashef、Maria Stefania Sinicropi、Rémi Legay、Aurélien Lesnard、Sylvain Rault

  DOI：10.1016/j.tet.2009.10.025

  日期：2009.12

  A one-pot synthesis of 2-dialkylamino-5,11-dimethyl-6H-pyrimido[5,4-b]carbazol-4(3H)-ones, as new ellipticine analogs, starting from aminocarbazole derivatives is reported. This method allowed us to prepare a library of potentially useful compounds in the pharmaceutical field. (C) 2009 Elsevier Ltd. All rights reserved.