2-[(2S,4R,5S)-6-[[(2R,4R,5S)-6-[[(2R,4R,5S)-3-(carboxymethoxy)-6-ethyl-4,5-dihydroxyoxan-2-yl]oxymethyl]-4,5-dihydroxy-3-[2-[6-(2-nitroimidazol-1-yl)hexylamino]-2-oxoethoxy]oxan-2-yl]oxymethyl]-4,5-dihydroxy-2-methyloxan-3-yl]oxyacetic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[(2S,4R,5S)-6-[[(2R,4R,5S)-6-[[(2R,4R,5S)-3-(carboxymethoxy)-6-ethyl-4,5-dihydroxyoxan-2-yl]oxymethyl]-4,5-dihydroxy-3-[2-[6-(2-nitroimidazol-1-yl)hexylamino]-2-oxoethoxy]oxan-2-yl]oxymethyl]-4,5-dihydroxy-2-methyloxan-3-yl]oxyacetic acid
• 化学式: C35H56N4O21
• 分子量: 868.8
• InChiKey: AOQVHRXQWSWUNR-SKXMZYPGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  60
• 可旋转键数：
  23
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  363
• 氢给体数：
  9
• 氢受体数：
  22

文献信息

• HYPOXIA-RESPONSIVE NANOPARTICLE FOR THERAPY AND IMAGING OF HYPOXIA-INVOLVING DISEASES
  申请人：RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY

  公开号：US20140141084A1

  公开（公告）日：2014-05-22

  The present invention relates to an amphiphilic polymer whose property and structure can change under hypoxic conditions, and to nanoparticles formed by self-assembly of the amphiphilic polymer. The hypoxia-responsive nanoparticles according to the present invention release a drug selectively under hypoxic conditions. Thus, the nanoparticles can be used for the selective diagnosis and treatment for diseases that are accompanied by hypoxia. Particularly, the nanoparticles can release a drug only to a targeted tumor in cancer therapy, and thus have minimized side effects and maximized therapeutic effects.

  本发明涉及一种在缺氧条件下其性质和结构可以改变的两性聚合物，以及由这种两性聚合物自组装形成的纳米粒子。根据本发明的缺氧响应性纳米粒子在缺氧条件下选择性地释放药物。因此，这些纳米粒子可用于对伴随缺氧的疾病进行选择性诊断和治疗。特别是，这些纳米粒子可以在癌症治疗中仅向靶向肿瘤释放药物，从而最大程度地减少副作用并最大化治疗效果。
• US9084806B2
  申请人：——

  公开号：US9084806B2

  公开（公告）日：2015-07-21