5-甲基-1,2,4-噻唑-3,4-二胺 | 21532-07-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 5-甲基-1,2,4-噻唑-3,4-二胺
• 英文名称: 3,4-diamino-5-methyl-1,2,4-triazole
• 英文别名: 3-methyl-4,5-diamino-1,2,4(4H)-triazole；5-methyl-[1,2,4]triazole-3,4-diyldiamine；5-Methyl-[1,2,4]triazol-3,4-diyldiamin；5-Methyl-4H-1,2,4-triazole-3,4-diamine；5-methyl-1,2,4-triazole-3,4-diamine
• CAS: 21532-07-0
• 化学式: C₃H₇N₅
• mdl: MFCD03789559
• 分子量: 113.122
• InChiKey: UHOFPBXQUTZOKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  82.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  5-甲基-1,2,4-噻唑-3,4-二胺 在 亚膦酸 、 sodium nitrite 作用下， 生成 3-甲基-1H-1,2,4-噻唑
  参考文献：
  名称：

  ACETYLATION AND RING CLOSURE IN REDUCTION OF NITRO- AND NITROAMINO-GUANIDINE¹

  摘要：

  DOI：

  10.1021/jo01130a014
• 作为产物：
  描述：

  2-氨基-5-甲基-1,3,4-恶二唑 在 一水合肼 作用下， 生成 5-甲基-1,2,4-噻唑-3,4-二胺
  参考文献：
  名称：

  Gehlen; Elchlepp, Justus Liebigs Annalen der Chemie, 1955, vol. 594, p. 14,20

  摘要：

  DOI：

文献信息

• NOVEL TETRACYCLIC INHIBITORS OF CYSTEINE PROTEASES, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS
  申请人：GUEDAT Philippe

  公开号：US20080103149A1

  公开（公告）日：2008-05-01

  The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use wherein R3, R4, R5, R6, Y, Het1, T, U, V, W, X, Ru, Rv and Rw are as defined in claim 1

  本发明涉及公式（I）的新化合物，它们的制备过程以及它们的治疗用途，其中R3、R4、R5、R6、Y、Het1、T、U、V、W、X、Ru、Rv和Rw的定义如权利要求1所述。
• Tetracyclic inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
  申请人：Hybrigenics S.A.

  公开号：EP1918292A1

  公开（公告）日：2008-05-07

  The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use wherein R3, R4, R5, R6, Y, Het1, T, U, V, W, X, Ru, Rv and Rw are as defined in claim 1

  本发明涉及公式（I）的新化合物，它们的制备过程以及它们的治疗用途，其中R3、R4、R5、R6、Y、Het1、T、U、V、W、X、Ru、Rv和Rw如权利要求1所定义。
• Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
  申请人：Hybrigenics S.A.

  公开号：EP1798232A1

  公开（公告）日：2007-06-20

  The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use, as inhibitors of cysteine proteases.

  本发明涉及公式（I）的新化合物，它们的制备过程以及作为半胱氨酸蛋白酶抑制剂的治疗用途。
• Acyclo<i>C</i>-Nucleoside Analogs. Regioselective Annellation of a Triazole Ring to 5-Methyl-1,2,4-Triazino[5,6-<i>b</i>]Indole and Formation of Certain 3-Poly Hydroxyalkyl Derivatives
  作者：Nagwa Rashed、Hamida Abdel Hamid、El Sayed Ramadan、El Sayed H. El Ashry

  DOI：10.1080/07328319808003476

  日期：1998.8

  Cyclodehydrogenation of the ethylidene derivative of (5-methyl-1,2,4-triazino[5,6-b]indol-3-yl)hydrazine (1) gave the angular isomer, 1,10-dimethyl-1,2,4-triazolo[3',4':3,4][1,2,4]triazino[5,6-b] (4) The linear isomer, 3,10-dimethyl- 1,2,4-triazolo[4',3':2,3][1,2,4]triazino[5,6-b ](7) could be prepared regioselectively by the cyclodehydration of the acetyl derivative of 1. The cyclodehydrogenation was extended to the monosaccharide derivatives of 1. The role of the N-methyl group on the site of annellation has been discussed.
• Shaban; Nasr; Morgaan, Pharmazie, 2002, vol. 57, # 7, p. 442 - 447
  作者：Shaban、Nasr、Morgaan

  DOI：——

  日期：——