[1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-methyl-2-oxo-7H-pyrrolo[2,3-d]pyrimidin-3-yl)oxolan-2-yl]-2-methylbutan-2-yl]oxy-(3-hydroxypentan-3-yl)phosphinic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-methyl-2-oxo-7H-pyrrolo[2,3-d]pyrimidin-3-yl)oxolan-2-yl]-2-methylbutan-2-yl]oxy-(3-hydroxypentan-3-yl)phosphinic acid
• 化学式: C₂₁H₃₄N₃O₈P
• 分子量: 487.5
• InChiKey: YWXVLKWBMWNDPG-OMBAOTTGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  161
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
  申请人：ModernaTX, Inc.

  公开号：US10258698B2

  公开（公告）日：2019-04-16

  The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.

  本公开特别提供了包含修饰核酸分子的制剂组合物，修饰核酸分子可编码蛋白质、蛋白质前体或蛋白质或蛋白质前体的部分或完全加工形式。制剂组合物可进一步包括修饰的核酸分子和递送剂。本发明进一步提供了用于编码能够调节细胞功能和/或活性的多肽的核酸。
• Alternative nucleic acid molecules and uses thereof
  申请人：ModernaTX, Inc.

  公开号：US10286086B2

  公开（公告）日：2019-05-14

  The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

  本公开提供了可供选择的核苷、核苷酸和核酸以及使用它们的方法。
• Modified polynucleotides for the production of secreted proteins
  申请人：ModernaTX, Inc.

  公开号：US10385106B2

  公开（公告）日：2019-08-20

  The present disclosure describes compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 5-methoxy-uridines to improve the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, protein half-life and/or modulation of a cell's status function, and/or activity.

  本公开内容描述了包括编码多肽的多核苷酸的组合物，这些多核苷酸通过用 5-甲氧基尿苷取代尿苷进行化学修饰，以改善组合物、与翻译机制的啮合、mRNA 半衰期、翻译效率、免疫逃避、蛋白质生产能力、分泌效率、进入循环的可及性、蛋白质半衰期和/或对细胞状态的调节、蛋白质半衰期和/或对细胞状态的调节功能和/或活性。
• Modified polynucleotides
  申请人：ModernaTX, Inc.

  公开号：US10501512B2

  公开（公告）日：2019-12-10

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

  本发明涉及制备、生产和治疗使用多核苷酸、初级转录本和 mmRNA 分子的组合物和方法。
• Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
  申请人：ModernaTX, Inc.

  公开号：US10463751B2

  公开（公告）日：2019-11-05

  The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.

  本发明涉及包括编码多肽的多核苷酸的组合物，这些组合物通过用 1-甲基假尿苷取代尿苷进行化学修饰，以改善组织中的一种或多种稳定性和/或清除率、受体摄取和/或动力学、组合物的细胞通路、与翻译机制的啮合、mRNA 半衰期、翻译效率、免疫逃避、蛋白质生产能力、分泌效率、循环通路、蛋白质半衰期和/或细胞状态、功能和/或活性的调节。