2-hydroxy-5-[[(Z)-(3-methyl-5-oxo-1H-pyrazol-4-ylidene)methyl]amino]benzaldehyde

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-hydroxy-5-[[(Z)-(3-methyl-5-oxo-1H-pyrazol-4-ylidene)methyl]amino]benzaldehyde
• 化学式: C₁₂H₁₁N₃O₃
• 分子量: 245.23
• InChiKey: KTFBGNLDMDEKMA-YHYXMXQVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  90.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE
  申请人：Zender Lars

  公开号：US20140141510A1

  公开（公告）日：2014-05-22

  The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.
• US9186381B2
  申请人：——

  公开号：US9186381B2

  公开（公告）日：2015-11-17