2,2,7-trimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2,7-trimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
• 化学式: C₁₀H₁₂N₂O₂
• 分子量: 192.21
• InChiKey: QBRBSMQSWOAOHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20140213585A1

  公开（公告）日：2014-07-31

  This invention is directed to methods of treating diseases or conditions associated with JAK2 activity in a mammal comprising the administration of a compound of formula (I): where n, m, Y, R 1 , R 2 , R 3 , R 4 and R 5 are disclosed herein, or a pharmaceutically acceptable salt.

  本发明涉及用于治疗哺乳动物中与JAK2活性相关疾病或病症的方法，包括给予以下公式（I）的化合物或其药学上可接受的盐：其中n，m，Y，R1，R2，R3，R4和R5在此被披露。
• NEW ANTIBACTERIAL COMPOUNDS
  申请人：Janssen Sciences Ireland UC

  公开号：EP2882739B1

  公开（公告）日：2017-05-03
• ANTIBACTERIAL COMPOUNDS
  申请人：JANSSEN SCIENCES IRELAND UC

  公开号：US20150210719A1

  公开（公告）日：2015-07-30

  The present invention is related to novel compounds of formula (I) that may inhibit the activity of the FabI enzyme, and which are useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
• Antibacterial compounds
  申请人：JANSSEN SCIENCES IRELAND UC

  公开号：US20150225424A1

  公开（公告）日：2015-08-13

  The present invention is related to novel compounds of formula (I) that may inhibit the activity of the FabI enzyme, and which are useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
• US8735418B2
  申请人：——

  公开号：US8735418B2

  公开（公告）日：2014-05-27