(2R,4R,5R)-5-acetamido-6-[(2S)-2,3-dihydroxypropyl]-2,4-dihydroxyoxane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,4R,5R)-5-acetamido-6-[(2S)-2,3-dihydroxypropyl]-2,4-dihydroxyoxane-2-carboxylic acid
• 化学式: C₁₁H₁₉NO₈
• 分子量: 293.27
• InChiKey: OJKMRYAMSZNUHX-HLIMEHJRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  157
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• Novel Uses of Neuraminidase Inhibitors in Infectious Diseases
  申请人：Broadhurst, III Jack J.

  公开号：US20140148511A1

  公开（公告）日：2014-05-29

  The present invention relates to methods of decreasing the infectivity, morbidity and rate of mortality, in treating diseases associated with a variety of pathogenic organisms, specifically diseases involving one or more pathogens that require neuraminidase as a virulence factor. In addition, the present invention uses biology based therapy to treat neuraminidase dependent infections or diseases dependent on sialic acid metabolism.
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC CONDITIONS AND NEUROMUSCULAR DISEASES<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT D'ÉTATS MÉTABOLIQUES ET DE MALADIES NEUROMUSCULAIRES
  申请人：KANDULA MAHESH

  公开号：WO2014122621A2

  公开（公告）日：2014-08-14

  The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing metabolic conditions and neuromuscular diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of myopathy, muscular diseases, metabolism related genetic disorders.