5-[3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-N-[(5R)-5-methyl-6-oxoheptyl]pentanamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-[3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-N-[(5R)-5-methyl-6-oxoheptyl]pentanamide
• 化学式: C₁₉H₃₆N₂O₇
• 分子量: 404.5
• InChiKey: ZHWJBIUZLXGJSG-OBRDOTTPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  28
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  151
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：US20150247143A1

  公开（公告）日：2015-09-03

  The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria.

  该发明涉及iRNA，例如双链核糖核酸（dsRNA），针对补体成分C5基因的组合物，以及使用这种iRNA，例如dsRNA，组合物来抑制C5的表达并治疗患有补体成分C5相关疾病的受试者，例如周期性夜间血红蛋白尿。
• COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF CD274/PD-L1 GENE
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20140148497A1

  公开（公告）日：2014-05-29

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the CD274/PD-L1 gene, and methods of using such dsRNA compositions to inhibit expression of CD274/PD-L1.
• ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：US20140179768A1

  公开（公告）日：2014-06-26

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ANGPTL3 gene, as well as methods of inhibiting expression of ANGPTL3 and methods of treating subjects having a disorder of lipid metabolism, such as hyperlipidemia or hypertriglyceridemia, using such dsRNA compositions.
• COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF TMPRSS6 GENE
  申请人：Bumcrot David

  公开号：US20140194489A1

  公开（公告）日：2014-07-10

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the TMPRSS6 gene, and methods of using such dsRNA compositions to inhibit expression of TMPRSS6.
• COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20150111841A1

  公开（公告）日：2015-04-23

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1.