(4S)-1,4-diamino-7-(diaminomethylamino)heptane-2,3-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4S)-1,4-diamino-7-(diaminomethylamino)heptane-2,3-dione
• 化学式: C₈H₁₉N₅O₂
• 分子量: 217.27
• InChiKey: IVLAILZOEDARMQ-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  150
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• HOMOGENEOUS ERYTHROPOIETIN AND METHOD FOR THEIR PREPARATION
  申请人：Sloan-Kettering Institute for Cancer Research

  公开号：EP2010556B1

  公开（公告）日：2015-09-23
• COMPOUNDS FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME
  申请人：Miao Yubin

  公开号：US20140147385A1

  公开（公告）日：2014-05-29

  The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
• US9393330B2
  申请人：——

  公开号：US9393330B2

  公开（公告）日：2016-07-19