(3Z,5E,9Z,11Z)-6-methyl-8-methylidenetrideca-1,3,5,9,11-pentaen-7-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3Z,5E,9Z,11Z)-6-methyl-8-methylidenetrideca-1,3,5,9,11-pentaen-7-one
• 化学式: C₁₅H₁₈O
• 分子量: 214.3
• InChiKey: VZUNTXJJQIYJCG-KMGKFGJASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] CHEMOTHERAPY FOR DRUG-RESISTANT CANCER CELLS<br/>[FR] CHIMIOTHÉRAPIE POUR DES CELLULES CANCÉREUSES RÉSISTANTES AUX MÉDICAMENTS
  申请人：UNIV SYDNEY

  公开号：WO2014078898A1

  公开（公告）日：2014-05-30

  The present invention relates to new treatments of multidrug resistant disorders, particularly cancers. There is provided a method of treating a cancer including administering an effective amount of a semicarbazone or hydrazone compound to a patient that has cancer, the cancer including a cancerous cell that includes an active efflux mechanism; wherein the compound is a substrate of the active efflux mechanism and the compound is able to form a chelation complex with a metal species in the cancerous cell, the chelation complex being cytotoxic to the cancerous cell.