1-[2-Methyl-4-[3-methyl-1-[2-(methylamino)ethoxy]pentan-3-yl]oxybutan-2-yl]oxypropan-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2-Methyl-4-[3-methyl-1-[2-(methylamino)ethoxy]pentan-3-yl]oxybutan-2-yl]oxypropan-2-one
• 英文别名: 1-[2-methyl-4-[3-methyl-1-[2-(methylamino)ethoxy]pentan-3-yl]oxybutan-2-yl]oxypropan-2-one
• 化学式: C₁₇H₃₅NO₄
• 分子量: 317.5
• InChiKey: JLNFHBNETPOTKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] SYNTHETIC LINEAR APELIN MIMETICS FOR THE TREATMENT OF HEART FAILURE<br/>[FR] MIMÉTIQUES D'APÉLINE LINÉAIRE SYNTHÉTIQUE POUR LE TRAITEMENT D'UNE INSUFFISANCE CARDIAQUE
  申请人：NOVARTIS AG

  公开号：WO2014081702A2

  公开（公告）日：2014-05-30

  The invention provides a synthetic polypeptide of Formula I': or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein X1, X2, X3, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides or bioconjugates thereof are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides or bioconjugates of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.