benzyl N-[(2S,3S,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(phenylmethoxy)oxan-3-yl]carbamate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: benzyl N-[(2S,3S,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(phenylmethoxy)oxan-3-yl]carbamate
• 化学式: C₃₅H₃₇NO₇
• 分子量: 583.7
• InChiKey: WGLHWIKOAYKWQO-OHBKMZHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  43
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  95.5
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• METHOD FOR DETECTING CANCER CELL USING FLUORESCENTLY LABELED L-GLUCOSE DERIVATIVE, AND CANCER CELL-IMAGING AGENT COMPRISING FLUORESCENTLY LABELED L-GLUCOSE DERIVATIVE
  申请人：Yamada Katsuya

  公开号：US20140154717A1

  公开（公告）日：2014-06-05

  The purpose of the present invention is to provide a method for highly accurately detecting a cancer cell. The method of the present invention is characterized by comprising imaging with the use of a fluorescently labeled L-glucose derivative. By using the method and imaging agent according to the present invention, a high contrast between a cancer cell and a normal cell can be obtained compared with the case that imaging is conducted with the use of a fluorescently labeled D-glucose derivative. According to this method, moreover, no fasting is needed for the determination. Thus, the imaging can be quickly carried out without imposing a burden on a patient.

  本发明的目的是提供一种高精度检测癌细胞的方法。本发明的方法的特点在于使用荧光标记的L-葡萄糖衍生物进行成像。通过使用本发明的方法和成像剂，与使用荧光标记的D-葡萄糖衍生物进行成像相比，可以获得癌细胞和正常细胞之间的高对比度。此外，根据本方法，不需要进行禁食以进行确定，因此可以在不对患者造成负担的情况下快速进行成像。