[2-(Chloromethyl)-2-octadecanoyl-3-oxoicosyl]-trimethylazanium

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [2-(Chloromethyl)-2-octadecanoyl-3-oxoicosyl]-trimethylazanium
• 英文别名: [2-(chloromethyl)-2-octadecanoyl-3-oxoicosyl]-trimethylazanium
• 化学式: C42H83ClNO2+
• 分子量: 669.6
• InChiKey: QUJHEURGGSNZQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17.1
• 重原子数：
  46
• 可旋转键数：
  37
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PROSTACYLIN COMPOSITIONS AND METHODS FOR USING THE SAME
  申请人：Insmed Incorporated

  公开号：EP2925303A1

  公开（公告）日：2015-10-07
• ULTRASOUND MEDIATED DELIVERY OF DRUGS
  申请人：Phoenix Solutions AS

  公开号：EP3049117A1

  公开（公告）日：2016-08-03
• [EN] PROSTACYLIN COMPOSITIONS AND METHODS FOR USING THE SAME<br/>[FR] COMPOSITIONS DE PROSTACYCLINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：INSMED INC

  公开号：WO2014085813A1

  公开（公告）日：2014-06-05

  The present invention relates to pharmaceutical compositions comprising a prostacyclin, a cationic compound, and a surfactant. Particulate compositions, including liposomal, solid nanoparticulate prostacyclin compositions, including treprostinil formulations comprising cationic compound and the surfactant are also described. The present invention also relates to a system comprising the pharmaceutical composition and an inhalation device. Methods for treating pulmonary hypertension and portopulmonary hypertension with the compositions and systems described herein are also provided.
• [EN] ULTRASOUND MEDIATED DELIVERY OF DRUGS<br/>[FR] ADMINISTRATION DE MÉDICAMENTS MÉDIÉE PAR ULTRASONS
  申请人：PHOENIX SOLUTIONS AS

  公开号：WO2015047103A1

  公开（公告）日：2015-04-02

  The present invention relates to ultrasound (US) mediated delivery of therapeutic agents, such as the delivery of a drug, gene, nanoparticle or radioisotope, using a bi-phasic microparticle system comprising gas microbubbles, emulsion microdroplets and clusters thereof. Thus, the present invention relates to a cluster composition and a pharmaceutical composition, and their use for delivery of therapeutic agents and as a contrast agent for ultrasound imaging. It further relates to methods for delivering such therapeutic agents and to the use of said compositions.