N-(1-hydroxy-3-oxopentan-2-yl)acetamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(1-hydroxy-3-oxopentan-2-yl)acetamide
• 化学式: C₇H₁₃NO₃
• 分子量: 159.18
• InChiKey: HHQNAFXDPXZQRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• PROCESS FOR THE SYNTHESIS OF LACOSAMIDE
  申请人：Euticals S.P.A.

  公开号：EP2528892B1

  公开（公告）日：2014-06-04
• Azoline Compound and Azole Compound Library and Method for Producing Same
  申请人：Suga Hiroaki

  公开号：US20140113830A1

  公开（公告）日：2014-04-24

  An object of the present invention is to provide a method of efficiently constructing a library abundant in diversity and also usable for screening of a compound that binds to a target substance having protease activity. The present invention provides a method of constructing an azoline compound library containing two or more azoline compounds having an azoline backbone introduced into at least one of Cys, Ser, Thr, and 2,3-diamino acid, and analogs thereof of Xaa 0 of a peptide represented by the following formula (I): A-(Xaa 0 ) n -B  (I) [wherein, m numbers of Xaa 0 s respectively represent arbitrary amino acids, at least one of which is an amino acid selected from the group consisting of Cys, Ser, Thr, and 2,3-diamino acid, and analogs thereof, m represents an inter selected from 2 to 40, and A and B each independently represent a peptide composed of from 0 to 100 amino acids].
• Method for Producing Compound Containing Heterocycle
  申请人：THE UNIVERSITY OF TOKYO

  公开号：US20160083719A1

  公开（公告）日：2016-03-24

  An object of the present invention is to provide a method of stably introducing a heterocycle into a substrate peptide by using an azoline backbone introducing enzyme. The present invention provides a method of introducing a heterocycle into a leader-sequence-free substrate peptide by using an azoline backbone introducing enzyme to which a leader sequence of the substrate has been bound.