(2,5-Dioxopyrrolidin-1-yl) 7-hydroxy-5-oxoheptanoate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2,5-Dioxopyrrolidin-1-yl) 7-hydroxy-5-oxoheptanoate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 7-hydroxy-5-oxoheptanoate
• 化学式: C₁₁H₁₅NO₆
• 分子量: 257.24
• InChiKey: MNEAKJWGZNQNHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Method of Relieving, Improving, Preventing or Treating Xerostomia
  申请人：SUNBIO INC.

  公开号：US20140155457A1

  公开（公告）日：2014-06-05

  Provided is a method of relieving, improving, preventing or treating xerostomia including applying an oral cavity composition including a polyethylene glycol (PEG) derivative whose reactor is modified to form a covalent bond with an epithelial cell of the oral cavity. An oral moisturizing effect and moisture persistency are increased and the method is effective against xerostomia due to aging or disease.
• CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS
  申请人：APELLIS PHARMACEUTICALS, INC.

  公开号：US20160194359A1

  公开（公告）日：2016-07-07

  In some aspects, the present invention provides cell-reactive compstatin analogs and compositions comprising cell-reactive compstatin analogs. In some aspects, the invention further provides methods of using cell-reactive compstatin analogs, e.g., treat a complement-mediated disorder, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ. In some aspects, the invention provides long-acting compstatin analogs and compositions comprising long-acting compstatin analogs. In some aspects, the invention further provides methods of using long-acting compstatin analogs, e.g., to treat a complement-mediated disorder, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ. In some aspects, the invention provides targeted compstatin analogs and compositions comprising targeted compstatin analogs. In some aspects, the invention further provides methods of using targeted compstatin analogs, e.g., to treat a complement-mediated disorder, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ