1-[4-[(4-Acetyl-3-hydroxy-2-propylphenyl)-ethyl-(hydroxymethyl)-lambda4-sulfanyl]-2,3-dimethylphenyl]ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-[(4-Acetyl-3-hydroxy-2-propylphenyl)-ethyl-(hydroxymethyl)-lambda4-sulfanyl]-2,3-dimethylphenyl]ethanone
• 英文别名: 1-[4-[(4-acetyl-3-hydroxy-2-propylphenyl)-ethyl-(hydroxymethyl)-λ4-sulfanyl]-2,3-dimethylphenyl]ethanone
• 化学式: C₂₄H₃₂O₄S
• 分子量: 416.6
• InChiKey: MVAWWCJKRZKFER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHOD OF TREATING LIVER DISORDERS
  申请人：MediciNova, Inc.

  公开号：US20140155484A1

  公开（公告）日：2014-06-05

  A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X 1 and X 2 are as defined herein, is useful for inhibiting liver steatosis, lobular inflammation, hepatic ballooning and hepatic scarring.
• METHOD OF INHIBITING OR TREATING FIBROSIS
  申请人：MediciNova, Inc.

  公开号：US20150342913A1

  公开（公告）日：2015-12-03

  A compound of Formula (I) or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein Formula (I), m, n, X 1 and X 2 are as defined herein, is useful for inhibiting, reducing, or treating fibrosis, conditions leading to or arising from it, and/or negative effects of each thereof.
• US8962687B2
  申请人：——

  公开号：US8962687B2

  公开（公告）日：2015-02-24
• US9498458B2
  申请人：——

  公开号：US9498458B2

  公开（公告）日：2016-11-22