[[3,4-Dihydroxy-5-(6-oxo-1,5,7,7a-tetrahydropyrrolo[2,3-b]pyridin-5-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [[3,4-Dihydroxy-5-(6-oxo-1,5,7,7a-tetrahydropyrrolo[2,3-b]pyridin-5-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• 英文别名: [[3,4-dihydroxy-5-(6-oxo-1,5,7,7a-tetrahydropyrrolo[2,3-b]pyridin-5-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• 化学式: C₁₂H₁₉N₂O₁₄P₃
• 分子量: 508.21
• InChiKey: NGAGEHDXFFKISR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.6
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  251
• 氢给体数：
  8
• 氢受体数：
  15

文献信息

• Modified polynucleotides for the production of secreted proteins
  申请人：ModernaTX, Inc.

  公开号：US10385106B2

  公开（公告）日：2019-08-20

  The present disclosure describes compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 5-methoxy-uridines to improve the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, protein half-life and/or modulation of a cell's status function, and/or activity.

  本公开内容描述了包括编码多肽的多核苷酸的组合物，这些多核苷酸通过用 5-甲氧基尿苷取代尿苷进行化学修饰，以改善组合物、与翻译机制的啮合、mRNA 半衰期、翻译效率、免疫逃避、蛋白质生产能力、分泌效率、进入循环的可及性、蛋白质半衰期和/或对细胞状态的调节、蛋白质半衰期和/或对细胞状态的调节功能和/或活性。
• MODIFIED POLYNUCLEOTIDES FOR TREATING ARGININOSUCCINATE SYNTHASE 1 PROTEIN DEFICIENCY
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140155472A1

  公开（公告）日：2014-06-05

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES ENCODING CD28 MOLECULE
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140171485A1

  公开（公告）日：2014-06-19

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR TREATING ARYLSULFATASE A PROTEIN DEFICIENCY
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140206755A1

  公开（公告）日：2014-07-24

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.