2-[1-[5-(Ethoxyamino)-2-formyl-3-hydroxy-6-methoxyoxan-4-yl]oxy-2,2-dihydroxyethoxy]-3-methoxybutanoic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[1-[5-(Ethoxyamino)-2-formyl-3-hydroxy-6-methoxyoxan-4-yl]oxy-2,2-dihydroxyethoxy]-3-methoxybutanoic acid
• 英文别名: 2-[1-[5-(ethoxyamino)-2-formyl-3-hydroxy-6-methoxyoxan-4-yl]oxy-2,2-dihydroxyethoxy]-3-methoxybutanoic acid
• 化学式: C₁₆H₂₉NO₁₂
• 分子量: 427.4
• InChiKey: LNHCVQRQVHHSOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  29
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  183
• 氢给体数：
  5
• 氢受体数：
  13

文献信息

• [EN] PHOTOREACTIVE DERIVATIVE OF HYALURONIC ACID, METHOD OF PREPARATION THEREOF, 3D-CROSSLINKED DERIVATIVE OF HYALURONIC ACID, METHOD OF PREPARATION AND USE THEREOF<br/>[FR] DÉRIVÉ PHOTORÉACTIF DE L'ACIDE HYALURONIQUE, SON PROCÉDÉ DE PRÉPARATION, DÉRIVÉ DE L'ACIDE HYALURONIQUE RÉTICULÉ DE FAÇON TRIDIMENSIONNELLE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
  申请人：CONTIPRO BIOTECH SRO

  公开号：WO2014082608A1

  公开（公告）日：2014-06-05

  The subject-matter of the invention is a photoreactive derivative of hyaluronic acid (formula I) and the method of preparation thereof, where first an aldehyde derivative of hyaluronic acid is prepared, oxidized in the position 6 of the glucosamine cycle and then the oxidized derivative reacts with an amine carrying a photoreactive species, for example l-(2- aminoethyl)pyridine-2(lH)-one, in the presence of a reducing agent, forming a photoreactive derivative. The prepared photoreactive derivative may be then photocrosslinked, wherein the reaction is based on [4+4] photocycloaddition. Moreover, the invention relates to a 3D- crosslinked derivative of hyaluronic acid (formula II) which exhibits an increased hydrolytic stability and improved sorption properties, with the possibility of a further design of the physical properties thereof according to the requirements of the final applications, and moreover, to the use thereof in tissue engineering, regenerative medicine, medical agents or formulations or cosmetics.