[1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-methyl-2-oxo-7H-pyrrolo[2,3-d]pyrimidin-3-yl)oxolan-2-yl]-2-methylbutan-2-yl]oxy-(1-hydroxyethyl)phosphinic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-methyl-2-oxo-7H-pyrrolo[2,3-d]pyrimidin-3-yl)oxolan-2-yl]-2-methylbutan-2-yl]oxy-(1-hydroxyethyl)phosphinic acid
• 化学式: C₁₈H₂₈N₃O₈P
• 分子量: 445.4
• InChiKey: REOWEPUAYDRNTD-ARNSMJQDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  161
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• MODIFIED POLYNUCLEOTIDES FOR TREATING CYSTIC FIBROSIS
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140155474A1

  公开（公告）日：2014-06-05

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• US20140255467A1
  申请人：——

  公开号：US20140255467A1

  公开（公告）日：2014-09-11
• US20140275229A1
  申请人：——

  公开号：US20140275229A1

  公开（公告）日：2014-09-18
• MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS
  申请人：Moderna Therapeutics, Inc.

  公开号：US20150246139A1

  公开（公告）日：2015-09-03

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MANUFACTURING METHODS FOR PRODUCTION OF RNA TRANSCRIPTS
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20160024547A1

  公开（公告）日：2016-01-28

  Described are methods for production of RNA transcripts using a non-amplified, linearized DNA template in an in vitro transcription reaction. Enzymatic 5 ′ capping and oligo dT purification can also be included in the methods.