1-[5-(4-Chlorobenzoyl)-1,4-dimethylpyrrol-2-yl]ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[5-(4-Chlorobenzoyl)-1,4-dimethylpyrrol-2-yl]ethanone
• 英文别名: 1-[5-(4-chlorobenzoyl)-1,4-dimethylpyrrol-2-yl]ethanone
• 化学式: C₁₅H₁₄ClNO₂
• 分子量: 275.73
• InChiKey: HCVAYRRETIXYGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  39.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• CXCR4 Receptor Compounds
  申请人：McMurry Thomas J.

  公开号：US20130210709A1

  公开（公告）日：2013-08-15

  The invention relates generally to compounds which are allosteric modulators (e.g., positive and negative allosteric modulators, and allosteric agonists) of the G protein coupled receptor for stromal derived factor 1 (SDF-I), also known as the CX-CR4 receptor. The CXCR4 receptor compounds are derived from the intracellular loops and domains of the CXCR4 receptor. The invention also relates to the use of these CXCR4 receptor compounds and pharmaceutical compositions comprising the CXCR4 receptor compounds in the treatment of diseases and conditions associated with CXCR4 modulation such as bone marrow trans-plantation, chemosensitization, cancer, metastatic disease, inflammatory diseases, HIV infection and stem cell-based regenerative medicine.
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC AND LIPID DISORDERS<br/>[FR] COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT DE TROUBLES MÉTABOLIQUES ET LIPIDIQUES
  申请人：KANDULA MAHESH

  公开号：WO2014083476A2

  公开（公告）日：2014-06-05

  The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing metabolic and lipid disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of diabetes, insulin resistance, hyperglycemia, hypertriglyceridemia, lipid disorders and cardiovascular diseases.