(2R,4R,5R)-2-(7-aminoimidazo[4,5-b]pyridin-3-yl)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]oxolane-3,3,4-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,4R,5R)-2-(7-aminoimidazo[4,5-b]pyridin-3-yl)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]oxolane-3,3,4-triol
• 英文别名: (2R,4R,5R)-2-(7-aminoimidazo[4,5-b]pyridin-3-yl)-5-[2-[dimethyl(methylidene)-λ5-phosphanyl]ethyl]oxolane-3,3,4-triol
• 化学式: C₁₅H₂₃N₄O₄P
• 分子量: 354.34
• InChiKey: FCKHYNYLXHZIIR-MPKXVKKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  127
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• MODIFIED POLYNUCLEOTIDES ENCODING ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140161873A1

  公开（公告）日：2014-06-12

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES ENCODING CITED4
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140186432A1

  公开（公告）日：2014-07-03

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• IN VIVO PRODUCTION OF PROTEINS
  申请人：Moderna Therapeutics, Inc.

  公开号：US20150111248A1

  公开（公告）日：2015-04-23

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF BIOLOGICS AND PROTEINS ASSOCIATED WITH HUMAN DISEASE
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160075733A1

  公开（公告）日：2016-03-17

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160354491A1

  公开（公告）日：2016-12-08

  The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.