(3S,4R,6R)-6-[(3S,4R,6S)-5-acetamido-6-[(3S,4R,6S)-6-[(3S,4R,6S)-5-acetamido-6-[(3S,4R,6R)-6-[(3S,4R,6S)-5-acetamido-4-hydroxy-2-(hydroxymethyl)-6-methyloxan-3-yl]oxy-2-[2-[3-[[benzyl(pyridin-2-ylmethyl)amino]methyl]-5-[[bis(pyridin-2-ylmethyl)amino]methyl]-4-hydroxyphenyl]ethylcarbamoyl]-4,5-dihydroxyoxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4,5-dihydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-N-(2-aminoethyl)-4,5-dihydroxy-3-methoxyoxane-2-carboxamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3S,4R,6R)-6-[(3S,4R,6S)-5-acetamido-6-[(3S,4R,6S)-6-[(3S,4R,6S)-5-acetamido-6-[(3S,4R,6R)-6-[(3S,4R,6S)-5-acetamido-4-hydroxy-2-(hydroxymethyl)-6-methyloxan-3-yl]oxy-2-[2-[3-[[benzyl(pyridin-2-ylmethyl)amino]methyl]-5-[[bis(pyridin-2-ylmethyl)amino]methyl]-4-hydroxyphenyl]ethylcarbamoyl]-4,5-dihydroxyoxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4,5-dihydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-N-(2-aminoethyl)-4,5-dihydroxy-3-methoxyoxane-2-carboxamide
• 化学式: C₈₁H₁₁₃N₁₁O₃₀
• 分子量: 1720.8
• InChiKey: MYBLFFDDZUPBRT-VNBDCZICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.1
• 重原子数：
  122
• 可旋转键数：
  36
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  590
• 氢给体数：
  19
• 氢受体数：
  36

文献信息

• NANOPARTICLES FOR DELIVERY OF LIGANDS
  申请人：The U.S.A, as represented by the Secretary, Department of Health & Human Services

  公开号：US20140162966A1

  公开（公告）日：2014-06-12

  Disclosed is a nanoparticulate complex comprising an artificial phosphate receptor of formula (I): P-[L-[-N(CH 2 -2-pyridyl) 2 ]] p .pZN 2+ (I) wherein P represents a nanoparticulate substrate, L represents a linking group, and p is an integer of ≧1. Also disclosed are a method for silencing a gene in a cancer patient in need thereof, a method for treating or preventing cancer in a patient in need thereof, and a method for targeting a cell in cancer treatment comprising use of the nanoparticulate complex, for example, a DPA/Zn-functionalized nanoparticulate complex.