4,4,5-Trimethyl-2-[(2-methylpropan-2-yl)oxy]hexan-3-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,4,5-Trimethyl-2-[(2-methylpropan-2-yl)oxy]hexan-3-one
• 英文别名: 4,4,5-trimethyl-2-[(2-methylpropan-2-yl)oxy]hexan-3-one
• 化学式: C₁₃H₂₆O₂
• 分子量: 214.34
• InChiKey: FQHARUAEKYWUQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Multistage Nanoparticle Drug Delivery System for the Treatment of Solid Tumors
  申请人：The Massachusetts General Hospital

  公开号：US20140161884A1

  公开（公告）日：2014-06-12

  Nanoparticles for a selective, two stage delivery to tumors have been developed. The nanoparticles are initially sized so that they preferentially accumulate in the tumor tissue as a result of leakage through the defective vascular in the solid tumors. Once in the tumor tissue, the nanoparticles are cleaved hydrolytically and/or by enzymatic cleavage over time to release smaller nanoparticles carrying therapeutic, prophylactic or diagnostic agents into the necrotic interior of the tumors. This provides a simple, elegant and highly effective means of delivery drug selectively not just to tumors generally, but, more importantly, into the poorly vascularized necrotic interiors which drugs are normally unable to penetrate. The nanoparticles have a number of advantages: less toxicity due to selective accumulation only in the tumors; access into the poorly vascularized necrotic interiors of the tumor; and sustained release over a period of time within the tumor.