(4-nitrophenyl) 5-[3-[(2S,6'R)-6'-[(1R)-1,2-dihydroxyethyl]-4',5',8-trihydroxy-7-(hydroxymethyl)spiro[3,5,7,8-tetrahydropyrano[4,3-b][1,4]oxathiine-2,2'-oxane]-5-yl]oxypropylamino]-5-oxopentanoate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4-nitrophenyl) 5-[3-[(2S,6'R)-6'-[(1R)-1,2-dihydroxyethyl]-4',5',8-trihydroxy-7-(hydroxymethyl)spiro[3,5,7,8-tetrahydropyrano[4,3-b][1,4]oxathiine-2,2'-oxane]-5-yl]oxypropylamino]-5-oxopentanoate
• 化学式: C28H38N2O15S
• 分子量: 674.7
• InChiKey: LOAHYKCJOGEVOA-UOPAEWKDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  46
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  285
• 氢给体数：
  7
• 氢受体数：
  16

文献信息

• IMMUNOGENIC SYNTHETIC GLYCOCONJUGATE FOR THE IMMUNOTHERAPY OF MELANOMA
  申请人：AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI (Italian Hospital)

  公开号：US20140161806A1

  公开（公告）日：2014-06-12

  A specific antibody against a compound of formula (I) wherein X is O, NH, S, CH 2 ; L is a linker that is a divalent spacer; A is an adjuvant or carrier that is an immunogenic molecule or an immunogenic particle; and wherein bonds between linker and saccharide moiety and between linker and carrier are of covalent type; wherein the linker L presents a chemical structure suitable to space the saccharide moiety and the carrier by 7-30 atoms when the adjuvant/carrier A is a biomacromolecule or by 19-30 atoms when the adjuvant/carrier A is a metallic nanoparticle; wherein the carrier/adjuvant A can be selected among a macromolecule, a macrocycle, a dendrimer, a liposome, a nanoparticle, an oligosaccharide featuring from two to five monosaccharidic units or cells like dendritic cells.
• US9255156B2
  申请人：——

  公开号：US9255156B2

  公开（公告）日：2016-02-09